TBC1D1

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesTBC1D1, TBC, TBC1, TBC1 domain family member 1

External IDsOMIM: 609850; MGI: 1889508; HomoloGene: 56856; GeneCards: TBC1D1; OMA:TBC1D1 - orthologs

Chr.Chromosome 4 (human)^[1]

Quick facts Available structures, PDB ...

TBC1D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QYE
Identifiers
Aliases	TBC1D1, TBC, TBC1, TBC1 domain family member 1
External IDs	OMIM: 609850; MGI: 1889508; HomoloGene: 56856; GeneCards: TBC1D1; OMA:TBC1D1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 37,891,084 bp[1] End 38,139,175 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 32.8 cM Start 64,313,648 bp[2] End 64,508,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone body of uterus muscle layer of sigmoid colon right coronary artery ganglionic eminence popliteal artery tibial arteries gastric mucosa left coronary artery ascending aorta Top expressed in muscle of thigh spermatocyte zygote retinal pigment epithelium choroid plexus of fourth ventricle granulocyte secondary oocyte right kidney spermatid plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytosol nucleus endomembrane system intracellular anatomical structure Biological process regulation of cilium assembly membrane organization regulation of protein localization activation of GTPase activity regulation of vesicle fusion intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23216 57915 Ensembl ENSG00000065882 ENSMUSG00000029174 UniProt Q86TI0 Q60949 RefSeq (mRNA) NM_001253912 NM_001253913 NM_001253914 NM_001253915 NM_015173 NM_001396959 NM_001289514 NM_019636 NM_001310611 RefSeq (protein) NP_001240841 NP_001240842 NP_001240843 NP_001240844 NP_055988 NP_001276443 NP_001297540 NP_062610 Location (UCSC) Chr 4: 37.89 – 38.14 Mb Chr 5: 64.31 – 64.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and cell differentiation. These proteins share significant homology with TRE2 (USP6), yeast Bub2, and CDC16 (White et al., 2000).[supplied by OMIM]^[6]