TBCD

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.[5]

AliasesTBCD, SSD-1, tfcD, tubulin folding cofactor D, PEBAT
End82,945,914 bp[1]
Quick facts Identifiers, Aliases ...
TBCD
Identifiers
AliasesTBCD, SSD-1, tfcD, tubulin folding cofactor D, PEBAT
External IDsOMIM: 604649; MGI: 1919686; HomoloGene: 4368; GeneCards: TBCD; OMA:TBCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033052
NM_005993

NM_029878

RefSeq (protein)

NP_005984

NP_084154

Location (UCSC)Chr 17: 82.75 – 82.95 MbChr 11: 121.34 – 121.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.[5]

Interactions

TBCD has been shown to interact with ARL2.[6][7]

References

Further reading

Related Articles

Wikiwand AI