TBL3

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.^[5][6]

AliasesTBL3, SAZD, UTP13, transducin beta like 3

External IDsOMIM: 605915; MGI: 2384863; HomoloGene: 4711; GeneCards: TBL3; OMA:TBL3 - orthologs

Chr.Chromosome 16 (human)^[1]

End1,982,929 bp^[1]

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TBL3
Identifiers
Aliases	TBL3, SAZD, UTP13, transducin beta like 3
External IDs	OMIM: 605915; MGI: 2384863; HomoloGene: 4711; GeneCards: TBL3; OMA:TBL3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,972,053 bp[1] End 1,982,929 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,916,923 bp[2] End 24,926,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gastrocnemius muscle apex of heart muscle of thigh skin of leg skin of abdomen ectocervix mucosa of transverse colon right lobe of thyroid gland Top expressed in spermatocyte epiblast spermatid morula embryo embryo ventricular zone Ileal epithelium maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding snoRNA binding RNA binding Cellular component Pwp2p-containing subcomplex of 90S preribosome small-subunit processome nucleolus nucleus nucleoplasm Biological process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10607 213773 Ensembl ENSG00000183751 ENSMUSG00000040688 UniProt Q12788 Q8C4J7 RefSeq (mRNA) NM_006453 NM_145396 RefSeq (protein) NP_006444 NP_663371 Location (UCSC) Chr 16: 1.97 – 1.98 Mb Chr 17: 24.92 – 24.93 Mb PubMed search [3] [4]
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The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.^[6]