TC-G 1005

TC-G 1005
Identifiers
	IUPAC name (4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dimethylphenoxy)pyridin-3-yl]methanone;
CAS Number	1415407-60-1;
PubChem CID	71450251;
ChemSpider	28663072;
ChEMBL	ChEMBL2181226;
Chemical and physical data
Formula	C25H25N3O2
Molar mass	399.494 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(C=C1)C)OC2=C(C=NC=C2)C(=O)N3CCN(C4=CC=CC=C43)C5CC5;
	InChI InChI=1S/C25H25N3O2/c1-17-7-8-18(2)24(15-17)30-23-11-12-26-16-20(23)25(29)28-14-13-27(19-9-10-19)21-5-3-4-6-22(21)28/h3-8,11-12,15-16,19H,9-10,13-14H2,1-2H3; Key:JQULIQJSYPZQMA-UHFFFAOYSA-N;

TC-G 1005 is an experimental drug which acts as a potent and selective agonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It is used for studying the function of this receptor, and has been found to induce secretion of glucagon-like peptide-1 and reduce blood glucose levels.^[1]^[2]

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Identifiers

IUPAC name (4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dimethylphenoxy)pyridin-3-yl]methanone
CAS Number	1415407-60-1
PubChem CID	71450251
ChemSpider	28663072
ChEMBL	ChEMBL2181226
Chemical and physical data
Formula	C₂₅H₂₅N₃O₂
Molar mass	399.494 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1)C)OC2=C(C=NC=C2)C(=O)N3CCN(C4=CC=CC=C43)C5CC5
InChI InChI=1S/C25H25N3O2/c1-17-7-8-18(2)24(15-17)30-23-11-12-26-16-20(23)25(29)28-14-13-27(19-9-10-19)21-5-3-4-6-22(21)28/h3-8,11-12,15-16,19H,9-10,13-14H2,1-2H3 Key:JQULIQJSYPZQMA-UHFFFAOYSA-N