TCF7L1

Transcription factor 7-like 1, also known as TCF7L1, is a human gene.^[5]

AliasesTCF7L1, TCF-3, TCF3, transcription factor 7 like 1

External IDsOMIM: 604652; MGI: 1202876; HomoloGene: 7563; GeneCards: TCF7L1; OMA:TCF7L1 - orthologs

Chr.Chromosome 2 (human)^[1]

End85,310,387 bp^[1]

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TCF7L1
Identifiers
Aliases	TCF7L1, TCF-3, TCF3, transcription factor 7 like 1
External IDs	OMIM: 604652; MGI: 1202876; HomoloGene: 7563; GeneCards: TCF7L1; OMA:TCF7L1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 85,133,392 bp[1] End 85,310,387 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 32.27 cM Start 72,603,361 bp[2] End 72,766,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries gastric mucosa ascending aorta Descending thoracic aorta subcutaneous adipose tissue left lobe of thyroid gland canal of the cervix right lobe of thyroid gland right coronary artery Top expressed in internal carotid artery external carotid artery genital tubercle vas deferens left colon ankle joint epiblast tunica media of zone of aorta abdominal wall ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding beta-catenin binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding Cellular component transcription regulator complex nucleus nucleoplasm cytosol Biological process regulation of Wnt signaling pathway chromatin organization Wnt signaling pathway transcription, DNA-templated canonical Wnt signaling pathway regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated beta-catenin-TCF complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83439 21415 Ensembl ENSG00000152284 ENSMUSG00000055799 UniProt Q9HCS4 Q9Z1J1 RefSeq (mRNA) NM_031283 NM_001079822 NM_009332 RefSeq (protein) NP_112573 NP_001073290 NP_033358 Location (UCSC) Chr 2: 85.13 – 85.31 Mb Chr 6: 72.6 – 72.77 Mb PubMed search [3] [4]
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This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.^[5]