TCIM

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TCIM is a protein that in humans is encoded by the TCIM gene.[5][6]

AliasesTCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
End40,155,310 bp[1]
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TCIM
Identifiers
AliasesTCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDsOMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020130

NM_026931

RefSeq (protein)

NP_064515

NP_081207

Location (UCSC)Chr 8: 40.15 – 40.16 MbChr 8: 24.93 – 24.93 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[6]

References

Further reading

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