TCIM
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
TCIM is a protein that in humans is encoded by the TCIM gene.[5][6]
AliasesTCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDsOMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Function
This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[6]