TDIQ

TDIQ, also known as MDTHIQ or MDA-CR, is a tetrahydroisoquinoline drug used in scientific research, which has anxiolytic and anorectic effects in animals.^[1][2] It has an unusual effects profile in animals, with the effects generalising to cocaine and partially to MDMA and ephedrine,^[3] but the effects did not generalise to amphetamine and TDIQ does not have any stimulant effects.^[4] It is thought these effects are mediated via a partial agonist action at α₂-adrenergic receptors, and TDIQ has been suggested as a possible drug for the treatment of cocaine dependence.^[5]

Other names6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Methylenedioxy-THIQ; MDTHIQ; MDA-CR; "MDA-Conformationally Restricted"; MDA-THIQ; MDA/THIQ

CAS Number

• 15052-05-8 ^Y

PubChem CID

• 27013

ChemSpider

• 25154

Quick facts Clinical data, Other names ...

TDIQ

Clinical data
Other names	6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Methylenedioxy-THIQ; MDTHIQ; MDA-CR; "MDA-Conformationally Restricted"; MDA-THIQ; MDA/THIQ
Identifiers
IUPAC name 5,6,7,8-Tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
CAS Number	15052-05-8 Y
PubChem CID	27013
ChemSpider	25154
UNII	N2NE2TM9ZF
CompTox Dashboard (EPA)	DTXSID00933985
Chemical and physical data
Formula	C10H11NO2
Molar mass	177.203 g·mol−1
3D model (JSmol)	Interactive image
SMILES c23OCOc2cc1CCNCc1c3
InChI InChI=1S/C10H11NO2/c1-2-11-5-8-4-10-9(3-7(1)8)12-6-13-10/h3-4,11H,1-2,5-6H2 Key:JHLDJOBIUVJSTG-UHFFFAOYSA-N
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