TEGT

TMBIM6
Identifiers
Aliases	TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDs	OMIM: 600748; MGI: 99682; HomoloGene: 2419; GeneCards: TMBIM6; OMA:TMBIM6 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,764,934 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,307,930 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; renal medulla; ; parotid gland; ; right testis; ; left testis; ; ventricular zone; ; gallbladder; ; mucosa of ileum; ; rectum; ; right adrenal cortex;
	Top expressed in
	lacrimal gland; ; vestibular membrane of cochlear duct; ; human kidney; ; submandibular gland; ; olfactory epithelium; ; granulocyte; ; epithelium of stomach; ; parotid gland; ; jejunum; ; intestinal villus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endoribonuclease inhibitor activity; protein binding; enzyme binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; mitochondrial membranes; integral component of plasma membrane; endoplasmic reticulum; nucleus;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of endoribonuclease activity; negative regulation of apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of protein binding; endoplasmic reticulum calcium ion homeostasis; response to endoplasmic reticulum stress; autophagy; response to unfolded protein; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; response to L-glutamate; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; apoptotic process; negative regulation of calcium ion transport into cytosol; negative regulation of RNA splicing; Unfolded Protein Response;
	Sources:Amigo / QuickGO
Orthologs
	7009
	110213
	ENSG00000139644
	ENSMUSG00000023010
	P55061
	Q9D2C7
	NM_001098576; NM_003217
	NM_001171034; NM_001171035; NM_001171036; NM_026669
	NP_001092046; NP_003208
	NP_001164505; NP_001164506; NP_001164507; NP_080945
	Wikidata
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