TFB1M

Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTFB1M, CGI75, mtTFB, mtTFB1, CGI-75, transcription factor B1, mitochondrial

External IDsOMIM: 607033; MGI: 2146851; HomoloGene: 9343; GeneCards: TFB1M; OMA:TFB1M - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts Available structures, PDB ...

TFB1M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GC5, 4GC9
Identifiers
Aliases	TFB1M, CGI75, mtTFB, mtTFB1, CGI-75, transcription factor B1, mitochondrial
External IDs	OMIM: 607033; MGI: 2146851; HomoloGene: 9343; GeneCards: TFB1M; OMA:TFB1M - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 155,256,134 bp[1] End 155,314,493 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 3,569,531 bp[2] End 3,608,056 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex left testis right testis right lobe of liver testicle Achilles tendon mucosa of transverse colon Top expressed in lumbar spinal ganglion primary oocyte seminiferous tubule zygote Paneth cell lacrimal gland endocardial cushion secondary oocyte left lobe of liver atrioventricular junction More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity DNA binding rRNA methyltransferase activity protein binding rRNA (adenine-N6,N6-)-dimethyltransferase activity RNA binding Cellular component mitochondrial matrix mitochondrial nucleoid mitochondrion Biological process rRNA processing methylation mitochondrion organization regulation of transcription, DNA-templated rRNA methylation transcription, DNA-templated rRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51106 224481 Ensembl ENSG00000029639 ENSMUSG00000036983 UniProt Q8WVM0 Q8JZM0 RefSeq (mRNA) NM_016020 NM_001350501 NM_001350502 NM_146074 RefSeq (protein) NP_057104 NP_001337430 NP_001337431 NP_666186 Location (UCSC) Chr 6: 155.26 – 155.31 Mb Chr 17: 3.57 – 3.61 Mb PubMed search [3] [4]
Wikidata
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TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.^[6][8][9]

Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.^[10] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.^[11]