TFB2M

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.^[5]

AliasesTFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial

External IDsOMIM: 607055; MGI: 107937; HomoloGene: 7362; GeneCards: TFB2M; OMA:TFB2M - orthologs

Chr.Chromosome 1 (human)^[1]

End246,566,261 bp^[1]

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TFB2M
Identifiers
Aliases	TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDs	OMIM: 607055; MGI: 107937; HomoloGene: 7362; GeneCards: TFB2M; OMA:TFB2M - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q44 Start 246,540,561 bp[1] End 246,566,261 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H4|1 83.56 cM Start 179,355,620 bp[2] End 179,373,832 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte palpebral conjunctiva right adrenal gland right adrenal cortex biceps brachii tibia left adrenal gland right lobe of liver parietal pleura Skeletal muscle tissue of biceps brachii Top expressed in muscle of thigh quadriceps femoris muscle muscle tissue skeletal muscle tissue tail of embryo zygote renal cortex proximal tubule heart epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity transcription coregulator activity rRNA methyltransferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity RNA binding Cellular component cell junction mitochondrial nucleoid mitochondrial matrix mitochondrion Biological process positive regulation of transcription, DNA-templated rRNA processing methylation mitochondrion organization regulation of transcription, DNA-templated rRNA methylation transcription, DNA-templated mitochondrial transcription transcription initiation from mitochondrial promoter rRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64216 15278 Ensembl ENSG00000162851 ENSMUSG00000026492 UniProt Q9H5Q4 Q3TL26 RefSeq (mRNA) NM_022366 NM_008249 NM_001331054 NM_001331055 RefSeq (protein) NP_071761 NP_001317983 NP_001317984 NP_032275 Location (UCSC) Chr 1: 246.54 – 246.57 Mb Chr 1: 179.36 – 179.37 Mb PubMed search [3] [4]
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This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.^[6]