GTF3A

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.^[5][6]

AliasesGTF3A, AP2, TFIIIA, general transcription factor IIIA

External IDsOMIM: 600860; MGI: 1913846; HomoloGene: 55630; GeneCards: GTF3A; OMA:GTF3A - orthologs

Chr.Chromosome 13 (human)^[1]

End27,435,823 bp^[1]

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GTF3A
Identifiers
Aliases	GTF3A, AP2, TFIIIA, general transcription factor IIIA
External IDs	OMIM: 600860; MGI: 1913846; HomoloGene: 55630; GeneCards: GTF3A; OMA:GTF3A - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.2 Start 27,424,619 bp[1] End 27,435,823 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,885,467 bp[2] End 146,892,424 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland glutes right ventricle middle temporal gyrus apex of heart biceps brachii thoracic diaphragm palpebral conjunctiva body of tongue Skeletal muscle tissue of biceps brachii Top expressed in otic placode saccule otic vesicle abdominal wall embryo tail of embryo epiblast primitive streak neural tube renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding DNA binding metal ion binding RNA binding 5S rRNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process rRNA transcription regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase III ribosomal large subunit biogenesis ribosome biogenesis regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2971 66596 Ensembl ENSG00000122034 ENSMUSG00000016503 UniProt Q92664 Q8VHT7 RefSeq (mRNA) NM_002097 NM_025652 RefSeq (protein) NP_002088 NP_079928 Location (UCSC) Chr 13: 27.42 – 27.44 Mb Chr 5: 146.89 – 146.89 Mb PubMed search [3] [4]
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It was first purified and identified as the first mammalian gene-specific activator by Robert G. Roeder in 1980,^[7] and later characterized by Wolffe and Brown in 1988.

The TFIIIA in Xenopus was the first zinc finger protein discovered.^[8]