TFMFly
Psychedelic drug
From Wikipedia, the free encyclopedia
TFMFly, or TFM-FLY, also known as DOTFM-FLY, is a serotonin receptor modulator of the phenethylamine, amphetamine and DOx, and FLY families related to psychedelics like DOTFM and DOB-FLY.[1][2][3]
- CA: Schedule I
- UK: Under Psychoactive Substances Act
- Unscheduled (in general)
- 780744-19-6
332012-20-1 (hydrochloride)
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| Other names | TFM-FLY; TFM-Fly; DOTFM-FLY |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist |
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| Formula | C14H16F3NO2 |
| Molar mass | 287.282 g·mol−1 |
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Pharmacology
Pharmacodynamics
It acts as a potent agonist at the 5HT2A serotonin receptor subtype, and is a chiral compound with the more active (R) enantiomer having a Ki of 0.12 nM at the human 5-HT2A receptor.[2] While the fully aromatic benzodifurans such as Bromo-DragonFLY generally have higher binding affinity than saturated compounds like 2C-B-FLY,[1] the saturated compounds have higher efficacy as agonists.[4]
Chemistry
Synthesis
The chemical synthesis of TFMFly has been described.[1]
Analogues
Analogues of TFMFly include DOTFM, DOB-FLY, and 25TFM-NBOMe, among others.
History
TFMFly was first reported by a team at Purdue University led by David E. Nichols in 2001.[1][3]