TGM3

Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTGM3, TGE, transglutaminase 3, UHS2

External IDsOMIM: 600238; MGI: 98732; HomoloGene: 20690; GeneCards: TGM3; OMA:TGM3 - orthologs

Chr.Chromosome 20 (human)^[1]

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TGM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L9M, 1L9N, 1NUD, 1NUF, 1NUG
Identifiers
Aliases	TGM3, TGE, transglutaminase 3, UHS2
External IDs	OMIM: 600238; MGI: 98732; HomoloGene: 20690; GeneCards: TGM3; OMA:TGM3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 2,296,001 bp[1] End 2,341,079 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 129,854,269 bp[2] End 129,892,319 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen right uterine tube tonsil minor salivary glands vagina ectocervix gallbladder blood granulocyte Top expressed in esophagus left colon lip superior surface of tongue granulocyte hair follicle skin of back skin of abdomen trachea pretectal area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding catalytic activity protein-glutamine gamma-glutamyltransferase activity transferase activity acyltransferase activity Cellular component extrinsic component of cytoplasmic side of plasma membrane extracellular exosome cytoplasm Biological process keratinization protein tetramerization hair follicle morphogenesis cell envelope organization peptide cross-linking keratinocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7053 21818 Ensembl ENSG00000125780 ENSMUSG00000027401 UniProt Q08188 Q08189 RefSeq (mRNA) NM_003245 NM_009374 RefSeq (protein) NP_003236 NP_033400 Location (UCSC) Chr 20: 2.3 – 2.34 Mb Chr 2: 129.85 – 129.89 Mb PubMed search [3] [4]
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Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.^[7]