THOC2

THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.^[5][6]

AliasesTHOC2, CXorf3, THO2, dJ506G2.1, hTREX120, MRX12, MRX35, THO complex 2

External IDsOMIM: 300395; MGI: 2442413; HomoloGene: 69669; GeneCards: THOC2; OMA:THOC2 - orthologs

Chr.X chromosome (human)^[1]

End123,733,056 bp^[1]

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THOC2
Identifiers
Aliases	THOC2, CXorf3, THO2, dJ506G2.1, hTREX120, MRX12, MRX35, THO complex 2
External IDs	OMIM: 300395; MGI: 2442413; HomoloGene: 69669; GeneCards: THOC2; OMA:THOC2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq25 Start 123,600,561 bp[1] End 123,733,056 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A4 Start 40,883,868 bp[2] End 41,009,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sural nerve ventricular zone epithelium of colon right lung visceral pleura left ovary gastric mucosa body of pancreas Top expressed in Rostral migratory stream sciatic nerve retinal pigment epithelium primitive streak ciliary body tail of embryo medullary collecting duct umbilical cord vestibular membrane of cochlear duct median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding mRNA binding Cellular component THO complex nuclear speck THO complex part of transcription export complex transcription export complex nucleus nucleoplasm Biological process poly(A)+ mRNA export from nucleus mRNA processing mRNA transport neuron development viral mRNA export from host cell nucleus RNA splicing generation of neurons RNA export from nucleus mRNA export from nucleus mRNA 3'-end processing cell morphogenesis blastocyst development regulation of gene expression regulation of mRNA export from nucleus negative regulation of neuron projection development stem cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57187 331401 Ensembl ENSG00000125676 ENSMUSG00000037475 UniProt Q8NI27 B1AZI6 RefSeq (mRNA) NM_001081550 NM_020449 NM_001033422 RefSeq (protein) NP_001075019 NP_001028594 Location (UCSC) Chr X: 123.6 – 123.73 Mb Chr X: 40.88 – 41.01 Mb PubMed search [3] [4]
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THO2 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[6]