TIAL1

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.^[5][6]

AliasesTIAL1, TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1

External IDsOMIM: 603413; MGI: 107913; GeneCards: TIAL1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 10 (human)^[1]

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TIAL1
Identifiers
Aliases	TIAL1, TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1
External IDs	OMIM: 603413; MGI: 107913; GeneCards: TIAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4G, 2CQI, 2DH7
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 119,571,802 bp[1] End 119,597,029 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 128,439,777 bp[2] End 128,461,717 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of uterus left ovary left lobe of thyroid gland muscle layer of sigmoid colon canal of the cervix tibia right ovary minor salivary glands skin of abdomen Top expressed in neural layer of retina cerebellar cortex ventricular zone epiblast medullary collecting duct Paneth cell spermatocyte paraventricular nucleus of hypothalamus arcuate nucleus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding DNA binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasm cytoplasmic stress granule lysosome extracellular exosome nucleus nucleoplasm ribonucleoprotein complex Biological process regulation of transcription by RNA polymerase II germ cell development defense response stem cell division positive regulation of cell population proliferation apoptotic process fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7073 21843 Ensembl ENSG00000151923 ENSMUSG00000030846 UniProt Q01085 P70318 RefSeq (mRNA) NM_001033925 NM_003252 NM_001323964 NM_001323965 NM_001323967 NM_001323968 NM_001323969 NM_001323970 NM_022333 NM_009383 NM_001347640 NM_001347641 RefSeq (protein) NP_001029097 NP_001310893 NP_001310894 NP_001310896 NP_001310897 NP_001310898 NP_001310899 NP_003243 NP_001334569 NP_001334570 NP_033409 Location (UCSC) Chr 10: 119.57 – 119.6 Mb Chr 7: 128.44 – 128.46 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been shown to function differently with respect to post-transcriptional silencing.^[6]