T-cell lymphoma invasion and metastasis-inducing protein 1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.[4][5][6]
AliasesTIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1, T-cell lymphoma invasion and metastasis 1
External IDsOMIM: 600687; MGI: 103306; HomoloGene: 2443; GeneCards: TIAM1; OMA:TIAM1 - orthologs
Structure
TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.
Function
TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.
Clinical significance
TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.