TICAM2

TICAM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M1W
Identifiers
Aliases	TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2, TIR domain containing adaptor molecule 2
External IDs	OMIM: 608321; MGI: 3040056; HomoloGene: 11014; GeneCards: TICAM2; OMA:TICAM2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	115,602,479 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	46,707,600 bp
RNA expression pattern
	Top expressed in
	monocyte; ; testicle; ; granulocyte; ; Achilles tendon; ; endometrium; ; Descending thoracic aorta; ; right adrenal cortex; ; stromal cell of endometrium; ; spleen; ; lymph node;
	Top expressed in
	ureter; ; granulocyte; ; epiblast; ; embryo; ; morula; ; tail of embryo; ; bone marrow; ; spleen; ; thymus; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; protein binding;
Cellular component	cytoplasm; endosome; late endosome; Golgi apparatus; early endosome membrane; membrane; late endosome membrane; plasma membrane; early endosome; endoplasmic reticulum; endosome membrane; secretory granule membrane;
Biological process	toll-like receptor 4 signaling pathway; negative regulation of chemokine (C-C motif) ligand 5 production; immune system process; TRAM-dependent toll-like receptor 4 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; inflammatory response; cellular response to lipopolysaccharide; I-kappaB kinase/NF-kappaB signaling; negative regulation of toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; signal transduction; necroptosis; apoptotic signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; innate immune response; neutrophil degranulation; positive regulation of chemokine (C-C motif) ligand 5 production; positive regulation of interleukin-18-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	353376
	225471
	ENSG00000243414
	ENSMUSG00000056130
	Q86XR7
	Q8BJQ4
	NM_021649
	NM_173394
	NP_067681; NP_001157940; NP_001157941
	NP_775570
	Wikidata
View/Edit Human	View/Edit Mouse

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene^[5]. Historically, it was often called TRIF-related adaptor molecule (TRAM)^[6].