TIMM10B

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesTIMM10B, FXC1, TIM10B, Tim9b, translocase of inner mitochondrial membrane 10 homolog B (yeast), translocase of inner mitochondrial membrane 10B

External IDsOMIM: 607388; MGI: 1315196; HomoloGene: 8142; GeneCards: TIMM10B; OMA:TIMM10B - orthologs

Chr.Chromosome 11 (human)^[1]

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TIMM10B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BSK
Identifiers
Aliases	TIMM10B, FXC1, TIM10B, Tim9b, translocase of inner mitochondrial membrane 10 homolog B (yeast), translocase of inner mitochondrial membrane 10B
External IDs	OMIM: 607388; MGI: 1315196; HomoloGene: 8142; GeneCards: TIMM10B; OMA:TIMM10B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,481,501 bp[1] End 6,484,681 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,640,056 bp[2] End 105,643,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibia sperm gonad saphenous vein epithelium of colon superior vestibular nucleus spinal ganglia ventral tegmental area amniotic fluid Top expressed in granulocyte right kidney embryo embryo muscle of thigh lip ventricular zone superior frontal gyrus yolk sac cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding Cellular component mitochondrial inner membrane mitochondrial intermembrane space mitochondrial intermembrane space protein transporter complex mitochondrion membrane TIM22 mitochondrial import inner membrane insertion complex Biological process protein transport protein targeting to mitochondrion cell-matrix adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26515 14356 Ensembl ENSG00000132286 ENSMUSG00000089847 UniProt Q9Y5J6 Q9WV96 RefSeq (mRNA) NM_012192 NM_019502 RefSeq (protein) NP_036324 NP_062375 NP_001346981 NP_001346982 NP_001346983 NP_001346984 NP_001346985 NP_001346987 NP_001346988 NP_001346989 NP_001346990 Location (UCSC) Chr 11: 6.48 – 6.48 Mb Chr 7: 105.64 – 105.64 Mb PubMed search [3] [4]
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FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]^[6]