TIMP3

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesTIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3

External IDsOMIM: 188826; MGI: 98754; HomoloGene: 36322; GeneCards: TIMP3; OMA:TIMP3 - orthologs

Chr.Chromosome 22 (human)^[1]

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TIMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CKI
Identifiers
Aliases	TIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDs	OMIM: 188826; MGI: 98754; HomoloGene: 36322; GeneCards: TIMP3; OMA:TIMP3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 32,801,705 bp[1] End 32,863,041 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 42.83 cM Start 86,136,236 bp[2] End 86,185,370 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint decidua retinal pigment epithelium urethra right lung lower lobe of lung vena cava saphenous vein upper lobe of lung upper lobe of left lung Top expressed in retinal pigment epithelium right kidney ciliary body right lung human kidney right lung lobe carotid body aortic valve skin of external ear iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity metal ion binding protease binding protein binding metalloendopeptidase inhibitor activity Cellular component extracellular matrix basement membrane extracellular exosome nucleus extracellular region platelet dense granule lumen extracellular space collagen-containing extracellular matrix Biological process cellular response to organic substance negative regulation of peptidase activity response to stimulus positive regulation of TRAIL-activated apoptotic signaling pathway negative regulation of ERK1 and ERK2 cascade negative regulation of membrane protein ectodomain proteolysis visual perception platelet degranulation response to organic substance negative regulation of metalloendopeptidase activity response to hormone negative regulation of endopeptidase activity response to cytokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7078 21859 Ensembl ENSG00000100234 ENSMUSG00000020044 UniProt P35625 P39876 RefSeq (mRNA) NM_000362 NM_011595 RefSeq (protein) NP_000353 NP_035725 Location (UCSC) Chr 22: 32.8 – 32.86 Mb Chr 10: 86.14 – 86.19 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.^[7]