Parathyroid hormone 2
Protein-coding gene in the species Homo sapiens
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An Error has occurred retrieving Wikidata item for infobox Tuberoinfundibular peptide of 39 residues (also called parathyroid hormone 2) is a protein that in humans is encoded by the PTH2 gene.[1][2]
TIP39 is related to parathyroid hormone and parathyroid hormone-related protein and is a ligand for the parathyroid hormone 2 receptor.[2]
The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [3]
Expression of TIP39 has been linked to social interaction in both zebrafish [4] and rats.[5] In these species, mutations of TIP39 or its receptor lead to abnormal social behavior.[6][7]
