Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.[5][6]
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TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM][6]
The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [7]
Expression of TIP39 has been linked to social interaction in both zebrafish [8] and rats.[9] In these species, mutations of TIP39 or its receptor lead to abnormal social behavior.[10][11]
