TLX3

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.^[5][6][7]

AliasesTLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3

External IDsOMIM: 604640; MGI: 1351209; HomoloGene: 23181; GeneCards: TLX3; OMA:TLX3 - orthologs

Chr.Chromosome 5 (human)^[1]

End171,312,139 bp^[1]

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TLX3
Identifiers
Aliases	TLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDs	OMIM: 604640; MGI: 1351209; HomoloGene: 23181; GeneCards: TLX3; OMA:TLX3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 171,309,248 bp[1] End 171,312,139 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 33,150,752 bp[2] End 33,153,589 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum C1 segment pituitary gland anterior pituitary olfactory zone of nasal mucosa Cortex of frontal lobe female reproductive system oviduct integument zone of skin Top expressed in lumbar spinal ganglion urethra female urethra male urethra neural tube enteric nervous system trigeminal ganglion embryo ganglion of vagus nerve glossopharyngeal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus nucleoplasm Biological process multicellular organism development regulation of respiratory gaseous exchange by nervous system process cell fate specification neuron fate specification central nervous system development neuron migration regulation of transcription, DNA-templated negative regulation of neuron differentiation respiratory gaseous exchange by respiratory system neuron differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30012 27140 Ensembl ENSG00000164438 ENSMUSG00000040610 UniProt O43711 O55144 RefSeq (mRNA) NM_021025 NM_019916 RefSeq (protein) NP_066305 NP_064300 Location (UCSC) Chr 5: 171.31 – 171.31 Mb Chr 11: 33.15 – 33.15 Mb PubMed search [3] [4]
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RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]^[7]