TMEM59

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.^[5][6]

AliasesTMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59

External IDsOMIM: 617084; MGI: 1929278; HomoloGene: 3583; GeneCards: TMEM59; OMA:TMEM59 - orthologs

Chr.Chromosome 1 (human)^[1]

End54,053,504 bp^[1]

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TMEM59
Identifiers
Aliases	TMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
External IDs	OMIM: 617084; MGI: 1929278; HomoloGene: 3583; GeneCards: TMEM59; OMA:TMEM59 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 54,026,681 bp[1] End 54,053,504 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C7|4 50.12 cM Start 107,035,596 bp[2] End 107,058,193 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa parotid gland bronchial epithelial cell right uterine tube C1 segment rectum corpus epididymis stromal cell of endometrium gallbladder mucosa of sigmoid colon Top expressed in renal cortex right kidney proximal tubule spermatocyte olfactory epithelium cochlea stomach synovial joint lens jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endopeptidase activity protein binding Cellular component integral component of membrane endosome late endosome Golgi apparatus late endosome membrane Golgi medial cisterna membrane Golgi membrane plasma membrane Golgi cis cisterna lysosomal membrane Golgi trans cisterna lysosome extracellular exosome Biological process positive regulation of autophagy proteolysis autophagy negative regulation of protein processing negative regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9528 56374 Ensembl ENSG00000116209 ENSMUSG00000028618 UniProt Q9BXS4 Q9QY73 RefSeq (mRNA) NM_001305043 NM_001305049 NM_001305050 NM_001305051 NM_001305052 NM_001305066 NM_004872 NM_029565 RefSeq (protein) NP_001291972 NP_001291978 NP_001291979 NP_001291980 NP_001291981 NP_001291995 NP_004863 NP_083841 Location (UCSC) Chr 1: 54.03 – 54.05 Mb Chr 4: 107.04 – 107.06 Mb PubMed search [3] [4]
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TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.^[7] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.^[7] Moreover, TMEM59 has been shown to potentiate wnt signaling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficacy of wnt signaling.^[8]