TMPRSS11D

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.^[5][6][7]

AliasesTMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP

External IDsOMIM: 605369; MGI: 2385221; HomoloGene: 74519; GeneCards: TMPRSS11D; OMA:TMPRSS11D - orthologs

Chr.Chromosome 4 (human)^[1]

End67,884,002 bp^[1]

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TMPRSS11D
Identifiers
Aliases	TMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP
External IDs	OMIM: 605369; MGI: 2385221; HomoloGene: 74519; GeneCards: TMPRSS11D; OMA:TMPRSS11D - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 67,820,876 bp[1] End 67,884,002 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 86,450,076 bp[2] End 86,521,279 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium cervix epithelium oral cavity body of tongue amniotic fluid mucosa of pharynx buccal mucosa cell periodontal fiber human penis Top expressed in esophagus external naris mucosa of esophagus epithelium of esophagus lip cervix cornea stomach neural layer of retina lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process respiratory gaseous exchange by respiratory system proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9407 231382 Ensembl ENSG00000153802 ENSMUSG00000061259 UniProt O60235 Q8VHK8 RefSeq (mRNA) NM_004262 NM_145561 RefSeq (protein) NP_004253 NP_663536 Location (UCSC) Chr 4: 67.82 – 67.88 Mb Chr 5: 86.45 – 86.52 Mb PubMed search [3] [4]
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This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.^[7]