TMPRSS6

TMPRSS6
Identifiers
Aliases	TMPRSS6, IRIDA, transmembrane protease, serine 6, matriptase-2, transmembrane serine protease 6
External IDs	OMIM: 609862; MGI: 1919003; HomoloGene: 12408; GeneCards: TMPRSS6; OMA:TMPRSS6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,109,563 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,352,834 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; lactiferous duct; ; pancreatic ductal cell; ; pituitary gland; ; anterior pituitary; ; right testis; ; cardia; ; left testis; ; putamen; ; secondary oocyte;
	Top expressed in
	left lobe of liver; ; otolith organ; ; utricle; ; olfactory epithelium; ; gallbladder; ; vestibular sensory epithelium; ; vestibular membrane of cochlear duct; ; embryo; ; embryo; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine-type peptidase activity; peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity; metalloendopeptidase activity;
Cellular component	membrane; integral component of membrane; intracellular anatomical structure; extracellular space; plasma membrane;
Biological process	membrane protein proteolysis; intracellular signal transduction; angiogenesis; fibrinolysis; negative regulation of BMP signaling pathway; self proteolysis; extracellular matrix organization; negative regulation of transcription, DNA-templated; proteolysis; cellular iron ion homeostasis; iron ion homeostasis; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; extracellular matrix disassembly; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	164656
	71753
	ENSG00000187045
	ENSMUSG00000016942
	Q8IU80
	Q9DBI0
	NM_001289000; NM_001289001; NM_153609
	NM_027902; NM_001355601
	NP_001275929; NP_001275930; NP_705837; NP_001361433
	NP_082178; NP_001342530
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene.^[5]

AliasesTMPRSS6, IRIDA, transmembrane protease, serine 6, matriptase-2, transmembrane serine protease 6

External IDsOMIM: 609862; MGI: 1919003; HomoloGene: 12408; GeneCards: TMPRSS6; OMA:TMPRSS6 - orthologs

Chr.Chromosome 22 (human)^[1]

End37,109,563 bp^[1]

Quick facts Identifiers, Aliases ...

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Based on twin studies, mutations in TMPRSS6 gene have a correlation with iron deficiency predisposition.^[6]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.^[5]

[5]

[1]

[2]

[3]

[4]

[6]

TMPRSS6

References

Further reading

Related Articles

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