TMTFA
Chemical compound
From Wikipedia, the free encyclopedia
TMTFA is an extremely potent acetylcholinesterase inhibitor. As a transition state analog of acetylcholinesterase, TMTFA is able to inhibit acetylcholinesterase at extremely low concentrations (within the femtomolar range), making it one of the most potent acetylcholinesterase inhibitors known.[2][3][4]
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| Names | |
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| Preferred IUPAC name
N,N,N-Trimethyl-3-(trifluoroacetyl)anilinium | |
| Identifiers | |
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3D model (JSmol) |
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| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C11H13F3NO | |
| Molar mass | 232.226 g·mol−1 |
| Hazards | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
1.6 mg/kg (intraperitoneal, mice) (as iodide salt)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action
TMTFA has a reactive ketone group that can covalently bind to the serine residue in the active site of acetylcholinesterase. This is due to the electron-withdrawing trifluoromethyl group on the carbonyl group.[5]