TNFSF18

Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18

External IDsOMIM: 603898; MGI: 2673064; HomoloGene: 3732; GeneCards: TNFSF18; OMA:TNFSF18 - orthologs

Chr.Chromosome 1 (human)^[1]

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TNFSF18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q1M, 2R30, 2R32, 3B93, 3B94
Identifiers
Aliases	TNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
External IDs	OMIM: 603898; MGI: 2673064; HomoloGene: 3732; GeneCards: TNFSF18; OMA:TNFSF18 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 173,039,202 bp[1] End 173,050,941 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.1|1 69.75 cM Start 161,322,224 bp[2] End 161,332,859 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gallbladder stromal cell of endometrium cartilage tissue rectum prefrontal cortex islet of Langerhans Brodmann area 9 smooth muscle tissue duodenum Top expressed in embryo uterus zone of skin lip spermatid spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity signaling receptor binding protein binding tumor necrosis factor receptor superfamily binding identical protein binding Cellular component integral component of membrane membrane plasma membrane extracellular space cell surface Biological process adaptive immune response positive regulation of leukocyte migration immune system process cell-cell signaling negative regulation of apoptotic process signal transduction positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity T cell proliferation involved in immune response tumor necrosis factor-mediated signaling pathway regulation of T cell proliferation positive regulation of cell adhesion positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8995 240873 Ensembl ENSG00000120337 ENSMUSG00000066755 UniProt Q9UNG2 Q7TS55 RefSeq (mRNA) NM_005092 NM_183391 RefSeq (protein) NP_005083 NP_899247 Location (UCSC) Chr 1: 173.04 – 173.05 Mb Chr 1: 161.32 – 161.33 Mb PubMed search [3] [4]
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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.^[7]