TNIP1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
TNFAIP3-interacting protein 1, also known as ABIN-1, is a protein that in humans is encoded by the TNIP1 gene.[5][6][7]
Association with autoimmune diseases
Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:
- Systemic Sclerosis;[8]
- Psoriasis;[9]
- Psoriatic arthritis;[10]
- Systemic Lupus Erythematosus[11][12]
- Type-1 autoimmune hepatitis[13]
- Lupus nephritis[14]
TNIP1 dysfunction or deficiency contributes to hyperinflammarion and may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure.[15]
Association with neurodegenerative diseases
A recent genome-wide association study (GWAS) has found that genetic variations in TNIP1 are associated with late-onset sporadic Alzheimer's disease (LOAD).[16]
Interactions
TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,[17] and has been shown to interact with TNFAIP3,[18] MAP3K1,[19] and MAPK1.[20]