TNRC6A

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.^[5][6]

AliasesTNRC6A, CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A

External IDsOMIM: 610739; MGI: 2385292; HomoloGene: 41399; GeneCards: TNRC6A; OMA:TNRC6A - orthologs

Chr.Chromosome 16 (human)^[1]

End24,827,632 bp^[1]

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TNRC6A
Identifiers
Aliases	TNRC6A, CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A
External IDs	OMIM: 610739; MGI: 2385292; HomoloGene: 41399; GeneCards: TNRC6A; OMA:TNRC6A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 24,610,209 bp[1] End 24,827,632 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2- F3 Start 122,723,108 bp[2] End 122,794,519 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon sural nerve cerebellum cerebellar hemisphere right hemisphere of cerebellum pituitary gland endometrium gastric mucosa left ovary Top expressed in ciliary body Gonadal ridge retinal pigment epithelium iris primitive streak arcuate nucleus median eminence lacrimal gland ventromedial nucleus parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component cytoplasm cytosol Golgi apparatus intracellular membrane-bounded organelle P-body nucleoplasm Biological process RNA interference gene silencing by miRNA regulation of translation miRNA-mediated gene silencing by inhibition of translation Wnt signaling pathway, calcium modulating pathway gene silencing regulation of gene silencing by miRNA regulation of megakaryocyte differentiation cellular response to starvation positive regulation of gene expression negative regulation of gene expression positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27327 233833 Ensembl ENSG00000090905 ENSG00000288130 ENSMUSG00000052707 UniProt Q8NDV7 Q3UHK8 RefSeq (mRNA) NM_014494 NM_001330520 NM_001351850 NM_144925 RefSeq (protein) NP_001317449 NP_055309 NP_001338779 NP_659174 Location (UCSC) Chr 16: 24.61 – 24.83 Mb Chr 7: 122.72 – 122.79 Mb PubMed search [3] [4]
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This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.^[6]