TOMM22

Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.^[5][6][7]

AliasesTOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22

External IDsOMIM: 607046; MGI: 2450248; HomoloGene: 10638; GeneCards: TOMM22; OMA:TOMM22 - orthologs

Chr.Chromosome 22 (human)^[1]

End38,685,421 bp^[1]

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TOMM22
Identifiers
Aliases	TOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22
External IDs	OMIM: 607046; MGI: 2450248; HomoloGene: 10638; GeneCards: TOMM22; OMA:TOMM22 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,681,957 bp[1] End 38,685,421 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,555,062 bp[2] End 79,557,601 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii mucosa of transverse colon rectum ganglionic eminence internal globus pallidus monocyte muscle of thigh apex of heart prefrontal cortex granulocyte Top expressed in spermatid spermatocyte morula neural tube epiblast mesencephalon ileum ganglionic eminence ventricular zone embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein transmembrane transporter activity protein binding Cellular component mitochondrial outer membrane translocase complex integral component of membrane mitochondrial inner membrane mitochondrial outer membrane integral component of mitochondrial outer membrane membrane mitochondrion Biological process protein transport protein targeting to mitochondrion protein import into mitochondrial matrix intracellular protein transport protein insertion into mitochondrial outer membrane macroautophagy transport positive regulation of apoptotic process protein insertion into mitochondrial membrane protein transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56993 223696 Ensembl ENSG00000100216 ENSMUSG00000022427 UniProt Q9NS69 Q9CPQ3 RefSeq (mRNA) NM_020243 NM_172609 RefSeq (protein) NP_064628 NP_766197 Location (UCSC) Chr 22: 38.68 – 38.69 Mb Chr 15: 79.56 – 79.56 Mb PubMed search [3] [4]
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The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane. The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane, to import cytosolic preproteins into the mitochondrion.^[7]