TOMM34

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.^[5][6]

AliasesTOMM34, HTOM34P, TOM34, URCC3, translocase of outer mitochondrial membrane 34

External IDsOMIM: 616049; MGI: 1914395; HomoloGene: 4956; GeneCards: TOMM34; OMA:TOMM34 - orthologs

Chr.Chromosome 20 (human)^[1]

End44,960,397 bp^[1]

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TOMM34
Identifiers
Aliases	TOMM34, HTOM34P, TOM34, URCC3, translocase of outer mitochondrial membrane 34
External IDs	OMIM: 616049; MGI: 1914395; HomoloGene: 4956; GeneCards: TOMM34; OMA:TOMM34 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,942,130 bp[1] End 44,960,397 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 163,895,460 bp[2] End 163,913,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis islet of Langerhans nucleus accumbens right uterine tube testicle right adrenal cortex caudate nucleus left adrenal gland putamen Top expressed in blood zygote cumulus cell subiculum pontine nuclei mesenteric lymph nodes primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding heat shock protein binding Cellular component integral component of membrane mitochondrial outer membrane membrane mitochondrion nucleus nucleoplasm cytoplasm cytosol Biological process protein targeting to mitochondrion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10953 67145 Ensembl ENSG00000025772 ENSMUSG00000018322 UniProt Q15785 Q9CYG7 RefSeq (mRNA) NM_006809 NM_001291155 NM_025996 RefSeq (protein) NP_006800 NP_001278084 NP_080272 Location (UCSC) Chr 20: 44.94 – 44.96 Mb Chr 2: 163.9 – 163.91 Mb PubMed search [3] [4]
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The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.^[6]