TOP3B

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.^[5][6][7]

AliasesTOP3B, TOP3B1, topoisomerase (DNA) III beta, DNA topoisomerase III beta

External IDsOMIM: 603582; MGI: 1333803; HomoloGene: 2923; GeneCards: TOP3B; OMA:TOP3B - orthologs

Chr.Chromosome 22 (human)^[1]

End21,982,813 bp^[1]

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TOP3B
Identifiers
Aliases	TOP3B, TOP3B1, topoisomerase (DNA) III beta, DNA topoisomerase III beta
External IDs	OMIM: 603582; MGI: 1333803; HomoloGene: 2923; GeneCards: TOP3B; OMA:TOP3B - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.22 Start 21,957,025 bp[1] End 21,982,813 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 16,688,600 bp[2] End 16,710,854 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum middle frontal gyrus frontal pole granulocyte right ovary stromal cell of endometrium left ovary Brodmann area 10 body of uterus canal of the cervix Top expressed in Epithelium of choroid plexus granulocyte spermatocyte choroid plexus of fourth ventricle neural layer of retina internal carotid artery right kidney superior frontal gyrus external carotid artery lip More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA topoisomerase type I (single strand cut, ATP-independent) activity protein binding isomerase activity RNA binding DNA topoisomerase activity Cellular component condensed chromosome nucleus Biological process chromosome segregation DNA topological change Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8940 21976 Ensembl ENSG00000100038 ENSMUSG00000022779 UniProt O95985 Q9Z321 RefSeq (mRNA) NM_001282112 NM_001282113 NM_003935 NM_001349845 NM_001349847 NM_001349848 NM_001349850 NM_001349851 NM_001349852 NM_011624 NM_001326576 RefSeq (protein) NP_001269041 NP_001269042 NP_003926 NP_001336774 NP_001336776 NP_001336777 NP_001336779 NP_001336780 NP_001336781 NP_001313505 NP_035754 Location (UCSC) Chr 22: 21.96 – 21.98 Mb Chr 16: 16.69 – 16.71 Mb PubMed search [3] [4]
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.^[7]