TRDMT1

tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesTRDMT1, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, tRNA aspartic acid methyltransferase 1

External IDsOMIM: 602478; MGI: 1274787; HomoloGene: 3249; GeneCards: TRDMT1; OMA:TRDMT1 - orthologs

Chr.Chromosome 10 (human)^[1]

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TRDMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G55
Identifiers
Aliases	TRDMT1, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, tRNA aspartic acid methyltransferase 1
External IDs	OMIM: 602478; MGI: 1274787; HomoloGene: 3249; GeneCards: TRDMT1; OMA:TRDMT1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 17,137,336 bp[1] End 17,202,054 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 13,513,825 bp[2] End 13,549,479 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone buccal mucosa cell Achilles tendon ganglionic eminence right uterine tube testicle epithelium of colon monocyte sural nerve gonad Top expressed in otic placode saccule otic vesicle atrioventricular valve spermatocyte granulocyte secondary oocyte zygote primitive streak primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity tRNA methyltransferase activity RNA binding tRNA (cytosine-5-)-methyltransferase activity Cellular component cytoplasm nucleus nucleoplasm Biological process response to amphetamine methylation tRNA methylation tRNA modification tRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1787 13434 Ensembl ENSG00000107614 ENSMUSG00000026723 UniProt O14717 O55055 RefSeq (mRNA) NM_004412 NM_176081 NM_176083 NM_176084 NM_176085 NM_176086 NM_001321006 NM_001321007 NM_001351219 NM_001351220 NM_001351221 NM_001351222 NM_001351223 NM_010067 RefSeq (protein) NP_001307935 NP_001307936 NP_004403 NP_001338148 NP_001338149 NP_001338150 NP_001338151 NP_001338152 NP_034197 Location (UCSC) Chr 10: 17.14 – 17.2 Mb Chr 2: 13.51 – 13.55 Mb PubMed search [3] [4]
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.^[8]

It has been shown that human DNMT2 does not methylate DNA but instead methylates cytosine 38 in the anticodon loop of aspartic acid transfer RNA (tRNA(Asp)).^[9]