TRIL (gene)

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

KIAA0644, also known as TRIL or TLR4 interactor with leucine rich repeats, is a protein that in humans is encoded by the KIAA0644 gene.[5]

AliasesTRIL, KIAA0644, TLR4 interactor with leucine rich repeats
End28,958,330 bp[1]
Quick facts Identifiers, Aliases ...
TRIL
Identifiers
AliasesTRIL, KIAA0644, TLR4 interactor with leucine rich repeats
External IDsOMIM: 613356; MGI: 1914123; HomoloGene: 69404; GeneCards: TRIL; OMA:TRIL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014817

NM_025817

RefSeq (protein)

NP_055632

NP_080093

Location (UCSC)Chr 7: 28.95 – 28.96 MbChr 6: 53.79 – 53.8 Mb
PubMed search[3][4]
Wikidata
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Function

The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.

TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).[6]

Protein sequence

The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet

Homology

KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.

Gene neighborhood

The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream [7][8]

References

Further reading

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