TRIM15

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.^[5][6][7][8]

AliasesTRIM15, RNF93, ZNF178, ZNFB7, tripartite motif containing 15

External IDsMGI: 1916347; HomoloGene: 23819; GeneCards: TRIM15; OMA:TRIM15 - orthologs

Chr.Chromosome 6 (human)^[1]

End30,172,693 bp^[1]

Quick facts Identifiers, Aliases ...

TRIM15
Identifiers
Aliases	TRIM15, RNF93, ZNF178, ZNFB7, tripartite motif containing 15
External IDs	MGI: 1916347; HomoloGene: 23819; GeneCards: TRIM15; OMA:TRIM15 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 30,163,206 bp[1] End 30,172,693 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 37,171,583 bp[2] End 37,178,102 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon rectum right lobe of liver gallbladder human kidney appendix epithelium of colon smooth muscle tissue islet of Langerhans Top expressed in intestinal villus ileum jejunum primary oocyte epithelium of small intestine duodenum secondary oocyte zygote yolk sac embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding Cellular component intracellular anatomical structure Biological process mesodermal cell fate determination positive regulation of DNA-binding transcription factor activity innate immune response positive regulation of RIG-I signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of type I interferon production negative regulation of intracellular transport of viral material Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89870 69097 Ensembl ENSG00000235960 ENSG00000227147 ENSG00000233599 ENSG00000204610 ENSG00000224145 ENSG00000235905 ENSG00000137384 ENSG00000235259 ENSMUSG00000050747 UniProt Q9C019 n/a RefSeq (mRNA) NM_033229 NM_052812 NM_001024134 NM_001177872 RefSeq (protein) NP_150232 n/a Location (UCSC) Chr 6: 30.16 – 30.17 Mb Chr 17: 37.17 – 37.18 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[8]