TRIM31

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesTRIM31, C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31

External IDsOMIM: 609316; MGI: 2385051; HomoloGene: 17137; GeneCards: TRIM31; OMA:TRIM31 - orthologs

Chr.Chromosome 6 (human)^[1]

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TRIM31
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YSJ, 2YSL
Identifiers
Aliases	TRIM31, C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31
External IDs	OMIM: 609316; MGI: 2385051; HomoloGene: 17137; GeneCards: TRIM31; OMA:TRIM31 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 30,102,897 bp[1] End 30,113,090 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 37,209,010 bp[2] End 37,221,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum duodenum appendix gallbladder urinary bladder testicle epithelium of colon right testis left testis Top expressed in intestinal villus jejunum duodenum left colon ileum epithelium of small intestine Paneth cell crypt of lieberkuhn of small intestine migratory enteric neural crest cell zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding transferase activity Cellular component cytoplasm cytosol intracellular anatomical structure mitochondrion Biological process positive regulation of DNA-binding transcription factor activity protein ubiquitination interferon-gamma-mediated signaling pathway negative regulation of viral transcription innate immune response negative regulation of viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11074 224762 Ensembl ENSG00000223531 ENSG00000137397 ENSG00000233573 ENSG00000224168 ENSG00000225130 ENSG00000226402 ENSG00000224542 ENSG00000204616 ENSMUSG00000058063 UniProt Q9BZY9 Q2L6J1 Q8R0K2 RefSeq (mRNA) NM_007028 NM_146077 RefSeq (protein) NP_008959 NP_008959.3 NP_666189 Location (UCSC) Chr 6: 30.1 – 30.11 Mb Chr 17: 37.21 – 37.22 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.^[6]