TRIM33
Protein-coding gene in the species Homo sapiens
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E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.[5] [6]
| TRIM33 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605769; MGI: 2137357; HomoloGene: 9296; GeneCards: TRIM33; OMA:TRIM33 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.[7]
Structure
The protein is a member of the tripartite motif family.[8] This motif includes three zinc-binding domains:
- RING
- B-box type 1 zinc finger
- B-box type 2 zinc finger
and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[7]