TRIM6

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.^[5][6]

AliasesTRIM6, RNF89, tripartite motif containing 6

External IDsOMIM: 607564; MGI: 2137352; HomoloGene: 14381; GeneCards: TRIM6; OMA:TRIM6 - orthologs

Chr.Chromosome 11 (human)^[1]

End5,612,958 bp^[1]

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TRIM6
Identifiers
Aliases	TRIM6, RNF89, tripartite motif containing 6
External IDs	OMIM: 607564; MGI: 2137352; HomoloGene: 14381; GeneCards: TRIM6; OMA:TRIM6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,596,109 bp[1] End 5,612,958 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 55.55 cM Start 103,868,000 bp[2] End 103,884,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte gonad human kidney parotid gland palpebral conjunctiva germinal epithelium tibia testicle parietal pleura Top expressed in yolk sac morula blastocyst embryo epiblast primitive streak spermatocyte embryo tail of embryo secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity protein tyrosine kinase binding ubiquitin protein ligase activity zinc ion binding transcription factor binding metal ion binding protein binding protein kinase binding transferase activity Cellular component cytoplasm cytosol intracellular anatomical structure nucleus Biological process positive regulation of transcription regulatory region DNA binding cellular response to virus positive regulation of type I interferon-mediated signaling pathway regulation of NIK/NF-kappaB signaling free ubiquitin chain polymerization cellular response to interferon-beta protein trimerization protein polyubiquitination negative regulation of gene expression positive regulation of peptidyl-serine phosphorylation negative regulation of stem cell differentiation response to lipopolysaccharide negative regulation of viral genome replication positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation protein ubiquitination negative regulation of transcription, DNA-templated positive regulation of defense response to virus by host viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117854 94088 Ensembl ENSG00000121236 ENSMUSG00000072244 UniProt Q9C030 Q8BGE7 RefSeq (mRNA) NM_058166 NM_001003818 NM_001198644 NM_001198645 NM_001013616 RefSeq (protein) NP_001003818 NP_001185573 NP_001185574 NP_477514 NP_001013637 Location (UCSC) Chr 11: 5.6 – 5.61 Mb Chr 7: 103.87 – 103.88 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.^[6]