TRIM68

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.^[5][6]

AliasesTRIM68, GC109, RNF137, SS-56, SS56, tripartite motif containing 68

External IDsOMIM: 613184; MGI: 2142077; HomoloGene: 9991; GeneCards: TRIM68; OMA:TRIM68 - orthologs

Chr.Chromosome 11 (human)^[1]

End4,608,231 bp^[1]

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TRIM68
Identifiers
Aliases	TRIM68, GC109, RNF137, SS-56, SS56, tripartite motif containing 68
External IDs	OMIM: 613184; MGI: 2142077; HomoloGene: 9991; GeneCards: TRIM68; OMA:TRIM68 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 4,598,672 bp[1] End 4,608,231 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 102,326,789 bp[2] End 102,336,534 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of bronchus bronchial epithelial cell prostate gonad right lobe of thyroid gland glomerulus metanephric glomerulus parietal pleura left lobe of thyroid gland Top expressed in lumbar spinal ganglion mucosa of urinary bladder transitional epithelium of urinary bladder genital tubercle lobe of prostate retinal pigment epithelium mammary gland Paneth cell urethra superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding androgen receptor binding histone acetyltransferase binding metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm perinuclear region of cytoplasm Golgi apparatus nucleolus intracellular anatomical structure nucleus cytosol Biological process interferon-gamma-mediated signaling pathway regulation of androgen receptor signaling pathway protein ubiquitination protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55128 101700 Ensembl ENSG00000167333 ENSMUSG00000073968 UniProt Q6AZZ1 Q8K243 RefSeq (mRNA) NM_018073 NM_001304496 NM_198012 NM_001307998 RefSeq (protein) NP_001291425 NP_060543 n/a Location (UCSC) Chr 11: 4.6 – 4.61 Mb Chr 7: 102.33 – 102.34 Mb PubMed search [3] [4]
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The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.^[6]