TRIP6

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesTRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
Quick facts Available structures, PDB ...
TRIP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDsOMIM: 602933; MGI: 1343458; HomoloGene: 37757; GeneCards: TRIP6; OMA:TRIP6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003302

NM_011639

RefSeq (protein)

NP_003293

NP_035769

Location (UCSC)Chr 7: 100.87 – 100.87 MbChr 5: 137.31 – 137.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]

Interactions

TRIP6 has been shown to interact with LPAR2,[8] BCAR1[8][9] and HOXA9.[10]

References

Further reading

Related Articles

Wikiwand AI