TRPM4

TRPM4
Identifiers
Aliases	TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6
External IDs	OMIM: 606936; MGI: 1915917; HomoloGene: 23033; GeneCards: TRPM4; OMA:TRPM4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,211,836 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,983,204 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; apex of heart; ; minor salivary glands; ; right uterine tube; ; skin of leg; ; skin of abdomen; ; Descending thoracic aorta; ; gallbladder; ; left lobe of thyroid gland;
	Top expressed in
	jejunum; ; duodenum; ; colon; ; ileum; ; vestibular membrane of cochlear duct; ; lip; ; left colon; ; muscle of thigh; ; stomach; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calcium channel activity; calmodulin binding; ion channel activity; ATP binding; sodium channel activity; calcium activated cation channel activity; calcium ion binding; metal ion binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; plasma membrane; nucleoplasm; endoplasmic reticulum; cytosol; soma; sodium channel complex; spanning component of plasma membrane; spanning component of membrane;
Biological process	adaptive immune response; vasoconstriction; immune system process; positive regulation of canonical Wnt signaling pathway; regulation of membrane potential; cation transport; ion transport; protein sumoylation; dendritic cell chemotaxis; regulation of T cell cytokine production; cardiac conduction; positive regulation of cell population proliferation; calcium ion transport; negative regulation of bone mineralization; positive regulation of atrial cardiac muscle cell action potential; positive regulation of heart rate; transmembrane transport; positive regulation of adipose tissue development; positive regulation of cytosolic calcium ion concentration; calcium ion transmembrane transport; positive regulation of fat cell differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of osteoblast differentiation; positive regulation of vasoconstriction; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization; ion transmembrane transport; calcium-mediated signaling; membrane depolarization during AV node cell action potential; membrane depolarization during Purkinje myocyte cell action potential; membrane depolarization during bundle of His cell action potential; regulation of heart rate by cardiac conduction; sodium ion import across plasma membrane; regulation of ventricular cardiac muscle cell action potential; protein homotetramerization; cellular response to ATP; inorganic cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54795
	68667
	ENSG00000130529
	ENSMUSG00000038260
	Q8TD43
	Q7TN37
NM_001195227; NM_017636; NM_001321281; NM_001321282; NM_001321283;
	NM_001321285
	NM_175130
NP_001182156; NP_001308210; NP_001308211; NP_001308212; NP_001308214;
	NP_060106
	NP_780339
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.^[5]^[6]