TRPM7
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.
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| Aliases | TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605692; MGI: 1929996; HomoloGene: 9774; GeneCards: TRPM7; OMA:TRPM7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[5]
