PKD2L1

PKD2L1
Identifiers
Aliases	PKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDs	OMIM: 604532; MGI: 1352448; GeneCards: PKD2L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TE3, 4GIF
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,330,264 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,180,881 bp
RNA expression pattern
	Top expressed in
	spleen; ; right frontal lobe; ; Brodmann area 9; ; sperm; ; glomerulus; ; right lung; ; anterior cingulate cortex; ; prefrontal cortex; ; placenta; ; mononuclear cell;
	Top expressed in
	lumbar subsegment of spinal cord; ; spermatocyte; ; seminiferous tubule; ; embryo; ; embryo; ; anterior horn of spinal cord; ; tongue; ; vallate papilla; ; gastrula; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium activated cation channel activity; muscle alpha-actinin binding; calcium channel activity; cation transmembrane transporter activity; calcium-activated potassium channel activity; sodium channel activity; cytoskeletal protein binding; protein binding; alpha-actinin binding; cation channel activity; identical protein binding; sour taste receptor activity;
Cellular component	integral component of membrane; cell projection; calcium channel complex; membrane; intracellular membrane-bounded organelle; receptor complex; plasma membrane; cilium; cell surface; endoplasmic reticulum; ciliary membrane; cation channel complex; non-motile cilium; integral component of plasma membrane; cytoplasmic vesicle;
Biological process	sodium ion transmembrane transport; cellular response to acidic pH; cation transport; sensory perception of sour taste; ion transport; protein homotrimerization; calcium ion transmembrane transport; detection of mechanical stimulus; potassium ion transmembrane transport; smoothened signaling pathway; detection of chemical stimulus involved in sensory perception of sour taste; calcium ion transport; response to water; detection of chemical stimulus involved in sensory perception of taste; protein tetramerization; protein homotetramerization; cellular response to pH; inorganic cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9033
	329064
	ENSG00000107593
	ENSMUSG00000037578
	Q9P0L9
	A2A259
	NM_001253837; NM_016112
	NM_181422
	NP_001240766; NP_057196
	NP_852087
	Wikidata
View/Edit Human	View/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 2 (TRPP2; formerly TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.^[5]