The TRPV3 channel is directly activated by various natural compounds like carvacrol, thymol and eugenol.[11] Several other monoterpenoids which cause either feeling of warmth or are skin sensitizers can also open the channel.[12] Monoterpenoids also induce agonist-specific desensitization of TRPV3 channels in a calcium-independent manner.[13]
Resolvin E1 (RvE1), RvD2, and 17R-RvD1 (see resolvins) are metabolites of the omega 3 fatty acids, eicosapentaenoic acid (for RvE1) or docosahexaenoic acid (for RvD2 and 17R-RvD1). These metabolites are members of the specialized proresolving mediators (SPMs) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, humans. These SPMs also dampen pain perception arising from various inflammation-based causes in animal models. The mechanism behind their pain-dampening effects involves the inhibition of TRPV3, probably (in at least certain cases) by an indirect effect wherein they activate other receptors located on neurons or nearby microglia or astrocytes. CMKLR1, GPR32, FPR2, and NMDA receptors have been proposed to be the receptors through which these SPMs operate to down-regulate TRPV3 and thereby pain perception.[14][15][16][17][18]
2-Aminoethoxydiphenyl borate (2-APB) is a mixed agonist-antagonist of the TRPV3 receptor, acting as an antagonist at low concentrations but showing agonist activity when used in larger amounts.[19] Drofenine also acts as a TRPV3 agonist in addition to its other actions.[20] Conversely, icilin has been shown to act as a TRPV3 antagonist, as well as a TRPM8 agonist.[21] Forsythoside B acts as a TRPV3 inhibitor among other actions.[22] Farnesyl pyrophosphate is an endogenous agonist of TRPV3,[23] while incensole acetate from frankincense also acts as an agonist at TRPV3.[24] TRPV3-74a is a selective TRPV3 antagonist.[25]
