TSC22D1

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.^[5][6]

AliasesTSC22D1, Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1

External IDsOMIM: 607715; MGI: 109127; HomoloGene: 7573; GeneCards: TSC22D1; OMA:TSC22D1 - orthologs

Chr.Chromosome 13 (human)^[1]

End44,577,147 bp^[1]

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TSC22D1
Identifiers
Aliases	TSC22D1, Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1
External IDs	OMIM: 607715; MGI: 109127; HomoloGene: 7573; GeneCards: TSC22D1; OMA:TSC22D1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 44,432,143 bp[1] End 44,577,147 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D3|14 40.44 cM Start 76,652,401 bp[2] End 76,745,205 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus tibia dorsal motor nucleus of vagus nerve postcentral gyrus beta cell entorhinal cortex mucosa of paranasal sinus caput epididymis Top expressed in iris medullary collecting duct renal corpuscle vestibular sensory epithelium epithelium of lens Epithelium of choroid plexus ciliary body condyle fossa vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8848 21807 Ensembl ENSG00000102804 ENSMUSG00000022010 UniProt Q15714 P62500 RefSeq (mRNA) NM_001243797 NM_001243798 NM_001243799 NM_006022 NM_183422 NM_001177751 NM_009366 NM_207652 NM_001310646 NM_001310647 RefSeq (protein) NP_001230726 NP_001230727 NP_001230728 NP_006013 NP_904358 NP_001171222 NP_001297575 NP_001297576 NP_033392 NP_997535 Location (UCSC) Chr 13: 44.43 – 44.58 Mb Chr 14: 76.65 – 76.75 Mb PubMed search [3] [4]
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TSC22 encodes a transcription factor and belongs to the large family of early response genes.^[7]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.^[8]