TSEN15

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[2][3][4]

Aliases5730449L18RikAL023077Sen15tRNA splicing endonuclease subunit 15

External IDsHomoloGene: 12002; GeneCards: ; OMA:- orthologs

Chr.Chromosome 1 (human)

End152,262,439 bp

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Tsen15
Identifiers
Aliases	5730449L18RikAL023077Sen15tRNA splicing endonuclease subunit 15
External IDs	HomoloGene: 12002; GeneCards: ; OMA:- orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1|1 G2 Start 152,246,486 bp End 152,262,439 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in yolk sac epiblast embryo ventricular zone embryo quadriceps femoris muscle olfactory bulb placenta heart skeletal muscle tissue n/a More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA-intron endonuclease activity molecular function nucleic acid binding nuclease activity Cellular component nucleolus nucleus cellular component Biological process mRNA processing tRNA splicing, via endonucleolytic cleavage and ligation RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing biological process nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 66637 n/a Ensembl ENSMUSG00000014980 n/a UniProt Q8R3W5 Q8R3W5 RefSeq (mRNA) NM_025677 n/a RefSeq (protein) NP_079953 NP_079953 Location (UCSC) Chr 1: 152.25 – 152.26 Mb n/a PubMed search [1] n/a
Wikidata
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tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[4]