Translin-associated factor X

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesTSNAX, TRAX, translin-associated factor X, translin associated factor X, C3PO
Quick facts TSNAX, Available structures ...
TSNAX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTSNAX, TRAX, translin-associated factor X, translin associated factor X, C3PO
External IDsOMIM: 602964; MGI: 1855672; HomoloGene: 4374; GeneCards: TSNAX; OMA:TSNAX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005999

NM_016909

RefSeq (protein)

NP_005990

NP_058605

Location (UCSC)Chr 1: 231.53 – 231.57 MbChr 8: 125.74 – 125.76 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.[6] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[7]

Interactions

TSNAX has been shown to interact with C1D.[8]

References

Further reading

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