TSPAN12
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.
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| Aliases | TSPAN12, EVR5, NET-2, NET2, TM4SF12, tetraspanin 12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613138; MGI: 1889818; HomoloGene: 8212; GeneCards: TSPAN12; OMA:TSPAN12 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Its main binding partner is the ADAM10 protein,[5] a sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and CD44.[6][7] It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function.[8] TSPAN12 also seems to regulate vascular development, as shown by a study involving TSPAN12 knockout mice.[9] TSPAN12 is a significant contributor to primary and metastatic cancer and is responsible for protecting β-catenin from degradation.[10]
