TSTA3

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesGFUS, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase

External IDsOMIM: 137020; MGI: 98857; HomoloGene: 2484; GeneCards: GFUS; OMA:GFUS - orthologs

Chr.Chromosome 8 (human)^[1]

Quick facts GFUS, Available structures ...

GFUS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B8W, 4BKP, 4E5Y, 4B8Z, 4BL5
Identifiers
Aliases	GFUS, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase
External IDs	OMIM: 137020; MGI: 98857; HomoloGene: 2484; GeneCards: GFUS; OMA:GFUS - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,612,618 bp[1] End 143,618,048 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D3|15 35.1 cM Start 75,796,525 bp[2] End 75,801,681 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach skin of abdomen mucosa of esophagus duodenum skin of leg salivary gland minor salivary glands body of pancreas mucosa of transverse colon fundus Top expressed in Paneth cell crypt of lieberkuhn of small intestine pyloric antrum large intestine colon lacrimal gland motor neuron duodenum seminal vesicula facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity GDP-4-dehydro-D-rhamnose reductase activity catalytic activity oxidoreductase activity GDP-L-fucose synthase activity isomerase activity identical protein binding GDP-mannose 3,5-epimerase activity Cellular component extracellular exosome cytosol cytoplasm Biological process GDP-mannose metabolic process leukocyte cell-cell adhesion metabolism cytolysis 'de novo' GDP-L-fucose biosynthetic process nucleotide-sugar biosynthetic process electron transport chain T cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7264 22122 Ensembl ENSG00000104522 ENSG00000278243 ENSMUSG00000022570 UniProt Q13630 P23591 RefSeq (mRNA) NM_003313 NM_001317783 NM_031201 NM_001357005 RefSeq (protein) NP_001304712 NP_003304 NP_112478 NP_001343934 Location (UCSC) Chr 8: 143.61 – 143.62 Mb Chr 15: 75.8 – 75.8 Mb PubMed search [3] [4]
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Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.^[8]