TTF2

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.^[5][6]

AliasesTTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2

External IDsOMIM: 604718; MGI: 1921294; HomoloGene: 37826; GeneCards: TTF2; OMA:TTF2 - orthologs

Chr.Chromosome 1 (human)^[1]

End117,107,453 bp^[1]

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TTF2
Identifiers
Aliases	TTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2
External IDs	OMIM: 604718; MGI: 1921294; HomoloGene: 37826; GeneCards: TTF2; OMA:TTF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 117,060,326 bp[1] End 117,107,453 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 100,938,860 bp[2] End 100,969,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve epithelium of colon Achilles tendon bone marrow cell gonad rectum epithelium of nasopharynx appendix mucosa of esophagus testicle Top expressed in hand primitive streak medullary collecting duct epiblast otic vesicle mandibular prominence maxillary prominence hair follicle endothelial cell of lymphatic vessel ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding ATP-dependent activity, acting on DNA zinc ion binding protein binding ATP binding helicase activity hydrolase activity Cellular component spliceosomal complex transcription elongation factor complex nucleus cytoplasm cytosol Biological process DNA-templated transcription, termination termination of RNA polymerase II transcription mRNA processing regulation of transcription, DNA-templated RNA splicing transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8458 74044 Ensembl ENSG00000116830 ENSMUSG00000033222 UniProt Q9UNY4 Q5NC05 RefSeq (mRNA) NM_003594 NM_001013026 RefSeq (protein) NP_003585 NP_001013044 Location (UCSC) Chr 1: 117.06 – 117.11 Mb Chr 3: 100.94 – 100.97 Mb PubMed search [3] [4]
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This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.^[6]