TUSC3

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTUSC3, D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, MagT2, SLC58A2

External IDsOMIM: 601385; MGI: 1933134; HomoloGene: 6937; GeneCards: TUSC3; OMA:TUSC3 - orthologs

Chr.Chromosome 8 (human)^[1]

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TUSC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M8G, 4M90, 4M91, 4M92
Identifiers
Aliases	TUSC3, D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, MagT2, SLC58A2
External IDs	OMIM: 601385; MGI: 1933134; HomoloGene: 6937; GeneCards: TUSC3; OMA:TUSC3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p22 Start 15,417,215 bp[1] End 15,766,649 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 39,472,999 bp[2] End 39,619,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell stromal cell of endometrium bronchial epithelial cell right adrenal cortex anterior pituitary left adrenal gland ventricular zone left adrenal cortex ganglionic eminence olfactory zone of nasal mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function magnesium ion transmembrane transporter activity dolichyl-diphosphooligosaccharide-protein glycotransferase activity Cellular component integral component of membrane oligosaccharyltransferase complex plasma membrane integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane mitochondrion Biological process protein N-linked glycosylation magnesium ion transport cognition transmembrane transport magnesium ion transmembrane transport protein glycosylation protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7991 80286 Ensembl ENSG00000104723 ENSMUSG00000118664 UniProt Q13454 Q8BTV1 RefSeq (mRNA) NM_006765 NM_178234 NM_001356429 NM_030254 NM_001357304 NM_001357305 NM_001357306 RefSeq (protein) NP_006756 NP_839952 NP_001343358 NP_084530 NP_001344233 NP_001344234 NP_001344235 Location (UCSC) Chr 8: 15.42 – 15.77 Mb Chr 8: 39.47 – 39.62 Mb PubMed search [3] [4]
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This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.^[7]